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Subject of Research: Medicine

Subject of Research: Medicine

Article Title: Divergent epigenetic profile underlie pubertal disorders in MKRN3-associated central precocious puberty and Prader–Willi syndrome: insights from a frameshift variant

Article References: Jin, Y.-Y., Wang, X., Yang, L., Mu, J., & Luo, F.-H. (2026). Divergent epigenetic profile underlie pubertal disorders in MKRN3-associated central precocious puberty and Prader–Willi syndrome: insights from a frameshift variant. World Journal of Pediatrics, 22(2), 258-271. https://doi.org/10.1007/s12519-026-01017-6

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DOI: 10.1007/s12519-026-01017-6

Keywords: central precocious puberty epigenetics, differential epigenetic profiles in pubertal diseases, epigenetic biomarkers for pubertal disorders, epigenetic modifications in developmental disorders, frameshift variants in MKRN3, genetic and epigenetic interplay in puberty, MKRN3 gene mutations, molecular basis of pubertal timing, neuroendocrine regulation of puberty, Prader-Willi syndrome epigenetic mechanisms, pubertal disorder epigenetic differences, role of MKRN3 in puberty regulation

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Juliet Wilcox. (August 31, 2026). Divergent epigenetic profile underlie pubertal disorders in MKRN3-associated central precocious puberty and Prader–Willi syndrome: insights from a frameshift variant. Scienmag. https://scienmag.com/divergent-epigenetic-profile-underlie-pubertal-disorders-in-mkrn3-associated-central-precocious-puberty-and-prader-willi-syndrome-insights-from-a-frameshift-variant/

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Tags: central precocious puberty epigeneticsdifferential epigenetic profiles in central precocious pubertydifferential epigenetic profiles in pubertal diseasesepigenetic biomarkers for pubertal disordersepigenetic modifications in developmental disordersepigenetic modifications in Prader–Willi syndromeframeshift variants in MKRN3frameshift variants in puberty regulationgenetic and epigenetic interplay in developmental disordersgenetic and epigenetic interplay in pubertyMKRN3 gene mutationsMKRN3 gene mutations and pubertymolecular basis of pubertal developmentmolecular basis of pubertal timingneuroendocrine regulation of pubertal timingneuroendocrine regulation of pubertyPrader-Willi syndrome epigenetic mechanismspubertal disorder epigenetic differencespubertal disorder epigeneticspubertal timing and epigenetic alterationsrole of MKRN3 in puberty regulation