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Subject of Research: Biology

Subject of Research: Biology

Article Title: Desiccation promotes DNA damage and rifampin resistance in Mycobacterium tuberculosis

Article References: Brown, C. D., Lee, B. M., Liu, H. M., Wu, A. M., Tellez, A., Zou, H., Singh, P. R., Saito, K., Mishra, S., Brown, M., Saleh, A., Odjourian, N. M., Cristaldo, M., Gan, M., Liu, Q., Gengenbacher, M., Darst, S. A., Campbell, E. A., Nathan, C., & Rhee, K. Y. (2026). Desiccation promotes DNA damage and rifampin resistance in Mycobacterium tuberculosis. Nature Microbiology. https://doi.org/10.1038/s41564-026-02437-w

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DOI: 10.1038/s41564-026-02437-w

Keywords: antibiotic resistance evolution, bacterial adaptation to dry conditions, bacterial desiccation tolerance, desiccation stress in tuberculosis, DNA repair mechanisms in M. tuberculosis, environmental stress effects on TB bacteria, genetic mutations induced by stress, impact of desiccation on bacterial genomes, Mycobacterium tuberculosis DNA damage, rifampin resistance development, survival strategies of Mycobacterium tuberculosis, tuberculosis treatment challenges

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Gavin Prescott. (August 31, 2026). Desiccation promotes DNA damage and rifampin resistance in Mycobacterium tuberculosis. Scienmag. https://scienmag.com/desiccation-promotes-dna-damage-and-rifampin-resistance-in-mycobacterium-tuberculosis/

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Tags: antibiotic resistance evolutionbacterial adaptation to dry conditionsbacterial desiccation tolerancedesiccationdesiccation stress in tuberculosisDNA damageDNA repair mechanisms in M. tuberculosisenvironmental stress effects on TB bacteriagenetic mutations induced by stressimpact of desiccation on bacterial genomesMycobacterium tuberculosisMycobacterium tuberculosis DNA damagerifampin resistancerifampin resistance developmentsurvival strategies of Mycobacterium tuberculosistuberculosis treatment challenges